About MOTS-C
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA region, placing it in the emerging class of mitochondrial-derived peptides that link organelle function to systemic metabolism. Its sequence, MRWQEMGYIFYPRKLR, is conserved across species and contains motifs that interact with cellular stress and nutrient-sensing pathways, including those downstream of AMPK and folate metabolism. Preclinical studies have examined MOTS-c in models of insulin sensitivity, exercise-induced metabolic adaptation, muscle oxidative capacity, and age-related metabolic decline. Because the peptide is moderately hydrophobic and contains both methionine and tryptophan residues, it is vulnerable to oxidation during synthesis and storage; oxidized forms can lose activity while remaining difficult to detect by routine HPLC alone. Shandong Shengyuan mitigates these risks through inert-atmosphere handling, RP-HPLC purity certification at 99.4% or higher, LC-MS identity confirmation, and stability-oriented lyophilization. Offered for research use only; not intended for human or veterinary use.
Research Applications
- Mitochondrial-derived peptide research
- AMPK and nutrient-sensing studies
- Exercise metabolism models
- Insulin sensitivity research
- Aging-related metabolic studies
Quality & Documentation
Every batch of MOTS-C is manufactured under our documented quality system and released with a Certificate of Analysis covering HPLC purity, mass spectrometry identity, peptide content, water content, and endotoxin. The batch code on your vial can be verified online in the COA lookup section of this site.
SS-31 Elamipretide 
NAD+ 
GHK-CU