About TB-500
TB-500 is a synthetic peptide corresponding to the actin-binding region of thymosin beta-4, built on the 16-amino-acid sequence LKKTETQEKQAGDAGE. This fragment retains the key actin-sequestering motif of the parent protein, making it a convenient probe for cytoskeletal research. Investigators study it in assays of actin polymerization, endothelial and fibroblast migration, angiogenesis-related cell behavior, and wound-closure models, where actin remodeling is a central readout. Because the peptide is short and rich in charged and polar residues, its biological activity is sensitive to oxidation, aggregation, and salt-form variability; low-purity material may contain deletion peptides that bind actin weakly or produce inconsistent dose-response curves. Shandong Shengyuan mitigates this with strict lyophilization controls, RP-HPLC purity testing to 99.3% or higher, accurate peptide-content and trifluoroacetate quantification, and LC-MS mass confirmation for every production lot. The product is provided as lyophilized powder for research use only and is not for human or veterinary application.
Research Applications
- Actin polymerization assays
- Cell migration and wound-closure models
- Angiogenesis research
- Cytoskeletal dynamics studies
- Tissue repair preclinical models
Quality & Documentation
Every batch of TB-500 is manufactured under our documented quality system and released with a Certificate of Analysis covering HPLC purity, mass spectrometry identity, peptide content, water content, and endotoxin. The batch code on your vial can be verified online in the COA lookup section of this site.
KPV 
BPC157 
BBKG80